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The Jonathan Demme Papers consist of materials related to Demme's extensive filmography from 1970-2008, including "The Silence of the Lambs". Materials are arranged chronologically by project, and cover most aspects of pre- and post-production, as well as publicity and related awards. As of September 2024, the "Silence of the Lambs," "Philadelphia," and "Rachel Getting Married" series has been processed and made available. Additional series will be completed at a later date.

The Jonathan Demme Papers consists of approximately 150 linear feet of materials from 1970-2010. Materials include correspondence, legal and business documents, and photographs, as well as extensive documentation of film production, including pre- and post-production phases. In some cases, awards and publicity materials are also included.

The "Silence of the Lambs" series consists of approximately 13 linear feet. The material follows the project through the phases of production, and includes many drafts of the final script and novel adaptation, as well as extensive pre-production and location scouting information.

The "Philadelphia" series consists of approximately 15 linear feet. Its material documents the 1993 courtroom drama starring Tom Hanks and Denzel Washington - regarded as Hollywood's seminal motion picture depicting the AIDS crisis and homophobia - through its development, production, promotion, exhibition, distribution, and reception. Its records show Demme's unique efforts to research AIDS and its effects on the gay community to give audiences an authentic portrayal of the crisis. Additionally, material from the Awards and Events sub-series highlights Demme's distinct concern for AIDS advocacy, support, and education, documenting the many philanthropic screenings benefiting AIDS-related organizations that coincided with the film's release.

The "Rachel Getting Married" series consists of approximately 6 linear feet. The material documents the 2008 drama, originally titled "Dancing with Shiva," starring Anne Hathaway, Rosemarie Dewitt, Bill Irwin and Debra Winger through the phases of its creation and promotion. Its records show Demme's unique approach to shooting the film as well as developing and recording the musical score.

As of September 2024, the "Silence of the Lambs", "Philadelphia", and "Rachel Getting Married" series have been processed and made available to researchers.