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Encourages William Mather to deliver a course of "chemical lectures" in Brownville and Watertown. Asks for details on a possible course and the number of lectures per day.

Notes on health. "I am following the proscriptions of a celebrated Root Doctor whose Medicines help me." His brother, Edmund, has not yet received a preaching position. Teaches thirty students and is living in a boarding house. Can see New York City, especially if he uses a spy glass. Comments on religion and his anxieties of his family's religious shortcomings.

Regarding being arrested for disinterring a corpse. Notes the amount of his bond and other financial difficulties.

Account of $132 owed to James P. Burke by the estate of J. D. Battle, settled April 25, 1866. Witnessed by G. B. Struther, Justice of the Peace, including two Internal Revenue stamps. Lists charges for medical practices, such as lancing wounds, extracting teeth, delivering children and a placenta, and prescribing medicine from September 1861 – January 1863. Includes charge for tending to an African American child.

Sorry to hear of Mr. L's illness, "but I suppose it is the wearing out of the machine, which is inevitable."

Notifying Eno that his brother (Henry Eno, 1798-1882?), has relapsed into alcoholism and his health is suffering. Describes his efforts to keep Eno’s brother sober, including offering him employment in his law office. His brother has been boarding at a tavern, has lost his job, and has not gone to church in three years. Believes he should return to his father’s house. Edw[in] Eno forwarded the letter to S[tephen] Eno (b. 1764), and included a note, dated December 29, 1830, admitting his bewilderment about Harry’s case but willingness to offer whatever aid he can.

Survey of land and the Ohio River in Ohio Territory Township 1, Second range. Surveyed in 1786 by Absalom Martin and in 1802 by Elnation Scofield. Includes drawings of the township and descriptions of the soil and trees.

Letter written to the sister of a deceased woman, detailing her last weeks alive. Describes the woman's illness, struggles with dysentery and a painful throat, visits by a doctor, and seeming recovery. Notes the woman tending to her child and her religious piety.

Writing to his brother in Springfield, Massachusetts, about a cholera epidemic that has spread from Montreal to Detroit. “It has been hitherto confined almost, if not wholly, to men of intemperate habits.” Mentions the deaths of five soldiers with the U.S. Army troops on their way to Chicago. Notes his estimates of cases and deaths overall. Believes that the Board of Health has acted “injudiciously” by not publishing bulletins warning the inhabitants and providing health advice. Acknowledges alarm and anxiety. Reports that he and Edward are staying at a home three-quarters of a mile from town “in a clean, airy situation” near a physician to ride out the wave of illness. Feels it is necessary to "guard our store, tho I do not expect to sell any goods."

Asks whether there are any cases of cholera in Philadelphia and how business, his own included, is going. He suffers from some symptoms of cholera, and his wife is experiencing "bilious colic." Plans to stay in Dover until they feel better and to avoid cholera.