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Discusses a possible map of Cincinnati. Describes the character and nationality of the people of Cincinnati and Kentucky.

Letter from Clements, Superintendent, written by Hen T. Koehne, Assistant Physician, on illustrated Southern Ohio State Insane Asylum, featuring an image of the exterior of the asylum and its grounds. Authorizing Smith "for ordering the removal of Michael Madden… He has been restored to perfect reason." Item arrived with American Philatelic Society description of the envelope stamp: "United States Scott No.11A, brownish carmine color of 1856, position 92L5L, used on cover with corner ad, genuine, sulphurized color."

Describes construction of a lighthouse at Minot’s Ledge. Gives specifications, cost, and difficulties faced. Discusses the family he boards with, newspapers, and briefly notes the politics of Fillmore and Fremont.

Requesting Chinese sugar cane seeds. Received "a package from you containing various kinds of garden seeds & an Agricultural Report-- The one I mentioned was the illustrated mechanical."

Wishes she could visit, but is deterred by the "fever and flux…raging in your neighborhood." Invites him to come visit instead.

Difficulties of maintaining epistolary contact. Family news, farming preparations, and tobacco cultivation. Comments on mental health of acquaintance, Stephen, currently at an asylum in Jacksonville. "... considered a hard subject to treat... He almost wore Eliza out with care and anxiety... He wrote that he was considered the most insane man there -- writes very intelligible and talks in the same way when he talks at all-- but he does not have but a few moments at a time but what the spitits are tempting him inflicting all kinds of pain, &c-- consequently, he is tumbling and rolling in all kinds of shape in order to resist as he calls it the spirits."

The physicians of the Boston Indian Medical Institute responding to an update about Bemis’ mother. Suggests bathing her arm in alcohol and water to reduce swelling, or "any local application you can make." Suspects that there is a circulation issue due to an obstruction. Written on the Indian Medical Institute letterhead with a detailed printed description of the institute on the back. Description includes a list of references and the names of the administrators and physicians.

Notes from a travelling salesman on medicine sales in Nashville, [Tennessee], and the area. Requests two or three thousand almanacs, finds them especially good to distribute in the Market House. Selling medicine, which local doctors oppose due to it infringing on their sales at drug stores. "...Made a Cure on a doctors Wife. he will send you a certificate of cure made." Has been travelling in Kentucky and Tennessee, stopping at "a great many P[ost] offices & store towns not on map." Notes the sale of 1860 almanacs written by Ayer and Jayne and his desire "to get ahead of them if I can."

Is retiring from ministry due to weak lungs. Hopes to begin a farm, but must teach to raise money. Has been reading about the science of agriculture, and describes how science informs farming practices. Advocates the benefits of an education for farmers. Gives details on crop rotation, raising and feeding cattle, and agricultural journals and books. [Incomplete]

Circular sent to agents of Louden & Co., listing the medicines they offer along with notes regarding the terms of sale. The medicines listed are: Indian Expectorant, Oriental Hair Tonic, Alternative or Sarsaparilla, Liquid Hair Dye, Female Elixir, Fever and Ague Pills, Pile Remedy, Compound Carminative Balsam, Compound Tonic Vermifuge, Indian Sanative Pills, All-Healing Salve, and Cherokee Liniment. Explains that "the medicines are charged to you at the net wholesale prices, at which you will account to us; the difference between the wholesale and retail prices being your profit or commission, for selling them." References almanacs and show cards that were also sent to the agents and explains the procedures for reporting their sales and making remittances. "N.B. – Please to read over carefully the 'Catalogue of Diseases and their Remedies,' which you will find in the 'Almanacs,' so that you may be able to determine at once which article would be the most appropriate to administer."