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Invoice for plants and seeds sent to John James in Urbana, Ohio. Written on printed letterhead for "Prince's Linnaean Botanic Garden and Nurseries," which includes a list of books for sale.

Writing on behalf of the superintendent of the poor for Ontario County, New York. Describes the case of Mary Webb who fell into mania after an out of wedlock pregnancy and miscarriage and who shows signs of nymphomania. Notes treatments attempted and ongoing symptoms.

Health of the family, including the death of newborn twins. Has been working a sawmill, providing details of their charges, difficulties with the river, and expectations for piloting logs to Natchez or New Orleans. Describes the land he acquired, improvements on it, and crops and livestock. Comments on the "bilious fever" caused by "a very great scent... which infected the atmosphere." Notes a Whig 4th of July Barbecue at Mount Carmel, Indiana. Describes the people in the region, noting their religion and lack of education. Discusses a cattle disease and its infection of people and dogs.

Severe illness, probably tuberculosis, prevents his return home. Describes his symptoms and the failure of treatments.

Has been unwell and too feeble to journey home. Skepticism of recent ‘spirit rapping’ demonstrations, and describes some doctors' investigations and debunking of them.

Encloses resolutions adopted by the Board of Trustees of the College of Pharmacy, New York City. Regards standards on imported drugs and the establishment of a national convention of pharmacists.

Writing "to let you kno that I am in the land of the living yet." Mrs. Champin died of smallpox, "she took it in the City." News of acquaintances, the sinking of the Schooner Empire. Advises them to avoid Philadelphia while smallpox "is so bad."

News that Nancy has been ill in the South with the Asiatic Cholera, also called the bloody flux, describing the disease's symptoms, treatment, and spread in the community, including among enslaved people on plantations. "One wealthy planter has a hundred sick servants every one upon the plantation except Arthur Whittle have had the disease…" Anxiety about her health and religious reflections. "Doct Farrar thinks she may be better, and that her throat may not trouble her as much after this; but you know her constitution is already thread bare; and how little confidence I have in what Physicians say."

Copy of a bill for amounts the County of Saratoga owes J[ames] H[enry] Salisbury at the State Laboratory for chemical analysis performed on specimens, per orders of William T. Odell, District Attorney. Describes the processes and analyses performed on samples, noting associated costs.

Responding to news from Bishop Paine of the formation of a committee including the Methodist Reverend Marshall and two other members of the Arkansas Conference to investigate his “pecuniary business." Cottingham purchased the right to sell Newsom’s Tonic Medicine from a man named Rosser, who claimed the medicine was patented. Cottingham sold the rights to several counties before realizing that Rosser had deceived him. Willing to make restitution if the committee feels that is necessary. “I do feel that restitution shall be made to some one, and brethren it is for you to say to whom, and how much.” Hopes the elders will inform Bishop Paine that he is working towards restitution and can take "charge of work in the Texas Conference."