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Apologizes for the delay in responding to Barden's letter, but "the small Pox has engrossed almost every moment of my time." Sending vaccines on quills, describing where the virus is located and how to best handle them. Comments on Barden's circumstances, his "scientific medical" work, and the manner with which his choice of home corresponds to what Dr. J[oseph] M[ather] Smith (1789-1866) taught them in regards to the impact of "air, exersize, diet, &c &c." Discusses his own work "to determine the extent to which vaccine proves a prophylactic against the Small Pox." Will be conducting experiments on cows produced by the "Governors of this Institution" [possibly the New York Dispensary].

Notification of election to the Academy of Natural Sciences as a corresponding member. Signed by Samuel George Morton. Written on official, illustrated letterhead.

Introducing Dr. Thomas Hunn, who will be traveling to Europe for medical and scientific education. Seeking letters of introduction to German, French, and English "savants." Comments on experiments on local magnetic fields.

Requests payment on an unpaid bill. Written on G. W. Carpenter's Chemical Warehouse illustrated stationery, with engraving of "Inspissated Extracts bottles (Quinine, Morphine, Cornine, and Piperine).

Description of bright flashing lights appearing in the sky in the early morning. "[I]t appeared as if all the stars were falling to the earth."

Discusses epidemics in New Orleans. Comments on newspaper reporting on them, cost of internment and its burden on the poor, and treatment of deceased slaves. Recovering from a case of bilious fever and diarrhea, which he attributes to using "Vegetable Hygean Pills." Speculating with wares to trade on the river and describes flat boats.

Writing to New York merchants about a shipment of Cayenne that was determined to be good quality. Despite the high quality, “Old Doctor viz Dr Saml. Thompson” believes that purchasing from them is “interfering with his business” and is likely to call on Seth Low to discuss the matter.

Seeking purchaser for William Phillips's mineral collection. If unable to sell as a collection, will have to sell it piecemeal in London.

In Philadelphia attending a course of lectures at the Jefferson Medical College, but has suffered a bout of "varioloid… (which is smallpox modified)." Describes his smallpox symptoms and medicines taken. Notes the death of two students from smallpox and Dr. Ely's providing a grave, "a portion of his own family Vault." Having experienced symptoms, he feels "secure in seeing small pox patients and have a better Idea of Eruptive diseases than theory could have given."

Cannot determine who could be able to purchase William Phillips's mineral collection. The University of Cambridge is unable to purchase it, as they already have a "very valuable, tho' imperfect minerealogical collection" and are undergoing costly construction and developments. Provides other individuals to forward the information on Phillips's collection.