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Has been preoccupied with his studies, including Greek, Latin, History, and Algebra. Sickness in the family, recommends their mother go "to the medicinal springs." Attributes a local death to drinking too much cold milk, as well as cases of cholera. Believes local outbreak of cholera has passed, and believes himself safer in Poughkeepsie than Montrose, Pennsylvania, on account of more experienced doctors. Poughkeepsie brought in nurses from New York City to aid in treatment of cholera. Notes recent deaths.

Informing Cellerier that the academic senate has forwarded his proposal. [In French]

Recently married and left Nashville. Recommends New Orleans as a place to live and make one's fortune. Does not need to leave New Orleans in the summer to escape yellow fever. Locals treat yellow fever with little fear and do not believe it contagious. Cholera abounds in New Orleans and in nearby plantations.

Apologizes for the delay in responding to Barden's letter, but "the small Pox has engrossed almost every moment of my time." Sending vaccines on quills, describing where the virus is located and how to best handle them. Comments on Barden's circumstances, his "scientific medical" work, and the manner with which his choice of home corresponds to what Dr. J[oseph] M[ather] Smith (1789-1866) taught them in regards to the impact of "air, exersize, diet, &c &c." Discusses his own work "to determine the extent to which vaccine proves a prophylactic against the Small Pox." Will be conducting experiments on cows produced by the "Governors of this Institution" [possibly the New York Dispensary].

Notification of election to the Academy of Natural Sciences as a corresponding member. Signed by Samuel George Morton. Written on official, illustrated letterhead.

Introducing Dr. Thomas Hunn, who will be traveling to Europe for medical and scientific education. Seeking letters of introduction to German, French, and English "savants." Comments on experiments on local magnetic fields.

Requests payment on an unpaid bill. Written on G. W. Carpenter's Chemical Warehouse illustrated stationery, with engraving of "Inspissated Extracts bottles (Quinine, Morphine, Cornine, and Piperine).

Description of bright flashing lights appearing in the sky in the early morning. "[I]t appeared as if all the stars were falling to the earth."

Discusses epidemics in New Orleans. Comments on newspaper reporting on them, cost of internment and its burden on the poor, and treatment of deceased slaves. Recovering from a case of bilious fever and diarrhea, which he attributes to using "Vegetable Hygean Pills." Speculating with wares to trade on the river and describes flat boats.