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The Smallpox Eradication (WHO) series (7.2 linear feet, 1 oversize folder, 1 film reel, and digital material (online)) documents efforts to eradicate smallpox around the world, principally in India. Material is dated from approximately 1953-2022 and includes correspondence, publications and reports, graphic medicine cartoons, photograph albums, a scrapbook, and audiovisual material.

Because of the overlap in content, researchers are encouraged to review of the content of multiple subseries.

The India subseries (2.7 linear feet and digital material (online)) consists of topical files—arranged into groupings based on the predominant type of material found in each file—documenting the WHO's and Government of India's campaign to surveil, contain and, ultimately, eradicate smallpox in India, principally in various administrative regions and municipalities within the states of Bihar and Uttar Pradesh. Notably represented are various kinds of reports that supported the surveillance-containment strategy, such as smallpox outbreak and containment reports, weekly epidemiological reports, and search summaries. At the end of the "Reports and Related Material" grouping is a "Various" file that includes topical files containing reports and related material about multiple administrative regions, districts, or villages.