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The Research and Practice series (1928-2017, 3.3 linear feet, oversize items, digital files, and archived website) includes writings by Kevorkian and annotated research articles as well as his correspondence on various medical, ethical, and bioethical topics, specifically organ transplantation and the death penalty. Correspondence contains Kevorkian's exchanges with medical professionals, politicians, publishers, and his supporters on the subjects of organ transplantation, terminally ill patients' rights and the Ninth Amendment of the Constitution, Medicide, death-row prisoners' right to die by euthanasia, and "prisoner procurement" (voluntary donation of organs by death-row prisoners). There are letters addressed to Kevorkian, supporting or disagreeing with his theories and methods. Correspondence is organized chronologically, except for one folder that contains Kevorkian's Armenian-language correspondence with Armenian scientists. Also found here are topical files on several subjects. The "Euthanasia" topical file contains articles that have been annotated by Kevorkian. The "Prisoner procurement" files include letters and petitions by prisoners on death-row who wanted their organs donated after being executed by euthanasia. More on the discussion of auctioning human organs and making them available for sale is found across the series, in correspondence, in Kevorkian's written work, and in a folder titled "Viscus global auction."

The series contains Kevorkian's published articles, monographs, and manuscript drafts. Folders with articles are arranged by decade; each contains a list of all articles published in the corresponding decade prepared by Ava Janus. Also found in this series is a folder containing material about the odontological dental retractor, a dental instrument that was invented by Kevorkian while he was imprisoned. The "Imprisonment" folder contains documents pertaining to his arrests, life in prison, parole hearings, and conditions of his parole.

Also found here are biographical sketches, published biographies and essays about Kevorkian, clippings of newspaper articles about him, his curriculum vitae, certificates, awards, diplomas, images of Dr. Kevorkian's paintings and information about his art, sheet music, and a small collection of his personal correspondence.

Photographs include images of Margaret and Ava Janus and Kevorkian's attorney, Geoffrey Fieger, as well as photographs of his medical instruments and personal effects. Digitized video recordings include compilations of recorded local news reports about Kevorkian as well as several special programs about his legal trial and about his work, aired on national television networks (e.g., Court TV, Frontline, 60 Minutes). Digitized audio recordings include his radio interviews (some given together with Fieger and others), recordings of his music, and music dedicated to him by others.

This series also includes Kevorkian's professional diplomas, certificates, and contents of the archived website, "The Kevorkian Papers." There is a framed portrait of Kevorkian, called "Dr. Life" by Rachel Reed, created in 1993. The portrait bears the inscription, "Go on because you know you are right." This portrait was used by Kevorkian's supporters during public events.